Unraveling the Mystery of Tuberculosis Heterogeneity
Recent advances in our understanding of tuberculosis infection demonstrate that infection within a given individual is highly heterogeneous; however, the determinants that drive lesions towards complete bacterial sterilization remain poorly understood.
Our Research
Recent advances in our understanding of tuberculosis infection demonstrate that infection within a given individual is highly heterogeneous; however, the determinants that drive lesions towards complete bacterial sterilization remain poorly understood.
Combining new technologies with classical approaches, we are focused ultimately on the goal to manipulate the immune system to improve bacterial control.
We are interested in developing new tools to dissect the complex dynamics of bacterial infection at a variety of scales ranging from single cells to infected hosts sitting in both “reference frames” by taking both an immunologist’s and a microbiologist’s perspective.
We are interested in developing new tools to dissect the complex dynamics of bacterial infection at a variety of scales ranging from single cells to infected hosts sitting in both “reference frames” by taking both an immunologist’s and a microbiologist’s perspective.
Current research projects are centered around two major questions:
To this end, we are pursuing several projects aimed at both answering these question directly and developing new tools to further our understanding of these complex host-pathogen interactions.
01
How can we...
reprogram phagocyte and phagosome function during infection?
02
How can we...
design vaccines, biologics, and other therapeutics that facilitate finding and eliminating pathogen-infected cells?
Media
Recent advances in our understanding of tuberculosis infection demonstrate that infection within a given individual is highly heterogeneous; however, the determinants that drive lesions towards complete bacterial sterilization remain poorly understood.
Combining new technologies with classical approaches, we are focused ultimately on the goal to manipulate the immune system to improve bacterial control.
We are interested in developing new tools to dissect the complex dynamics of bacterial infection at a variety of scales ranging from single cells to infected hosts sitting in both “reference frames” by taking both an immunologist’s and a microbiologist’s perspective.
Publications
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Lab Location
Ragon Institute
600 Main Street
Cambridge, MA 02139
600 Main Street
Cambridge, MA 02139
Our lab space and offices are located in the brand new Ragon Institute equipped with state of the art microscopy, flow cytometry and BSL3 research facilities.
